1,124 research outputs found

    PIH16 analyzing the Adverse Drug reactions of Geriatric Population at A regional Academic Hospital of southern Taiwan

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    "Forbidden" transitions between quantum Hall and insulating phases in p-SiGe heterostructures

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    We show that in dilute metallic p-SiGe heterostructures, magnetic field can cause multiple quantum Hall-insulator-quantum Hall transitions. The insulating states are observed between quantum Hall states with filling factors \nu=1 and 2 and, for the first time, between \nu=2 and 3 and between \nu=4 and 6. The latter are in contradiction with the original global phase diagram for the quantum Hall effect. We suggest that the application of a (perpendicular) magnetic field induces insulating behavior in metallic p-SiGe heterostructures in the same way as in Si MOSFETs. This insulator is then in competition with, and interrupted by, integer quantum Hall states leading to the multiple re-entrant transitions. The phase diagram which accounts for these transition is similar to that previously obtained in Si MOSFETs thus confirming its universal character

    Study of the Anti-Proliferative Activity of 5-Substituted 4,7-Dimethoxy-1,3-Benzodioxole Derivatives of SY-1 from Antrodia camphorata on Human COLO 205 Colon Cancer Cells

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    A set of 10 4,7-dimethoxy-1,3-benzodioxole derivatives based on a lead compound previously discovered by our group, SY-1, which was isolated from Antrodia camphorata, were evaluated for their in vitro inhibitory activity on human colorectal carcinoma cells (COLO 205). Structure-activity relationship studies of the 10 compounds indicated the importance of the chain length of the alkyl group at the 5-position, and the 2-propenyl substituent named “apiole” exhibited the most potent inhibitory activity. In the present study, we demonstrate that the SY-1 analogue “apiole” decreased the proliferation of COLO 205 cells, but not that of normal human colonic epithelial cells (FHC). The G0/G1 cell cycle arrest induced by apiole (75–225 μM) was associated with significantly increased levels of p53, p21 and p27 and decreased levels of cyclin D1. Concerning COLO 205 cell apoptosis, apiole (>150 μM) treatment significantly increased the levels of cleaved caspases 3, 8, 9 and bax/bcl-2 ratio and induced ladder formation in DNA fragmentation assay and sub-G1 peak in flow cytometry analysis. These findings suggest that apiole can suppress COLO 205 cell growth; however, the detailed mechanisms of these processes require further investigation

    Energy Release During Slow Long Duration Flares Observed by RHESSI

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    Slow Long Duration Events (SLDEs) are flares characterized by long duration of rising phase. In many such cases impulsive phase is weak with lack of typical short-lasting pulses. Instead of that smooth, long-lasting Hard X-ray (HXR) emission is observed. We analysed hard X-ray emission and morphology of six selected SLDEs. In our analysis we utilized data from RHESSI and GOES satellites. Physical parameters of HXR sources were obtained from imaging spectroscopy and were used for the energy balance analysis. Characteristic time of heating rate decrease, after reaching its maximum value, is very long, which explains long rising phase of these flares.Comment: Accepted for publication in Solar Physic
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